Acepromazine Maleate (PromAce®)

Introduction to acepromazine

Acepromazine is a medication primarily used to sedate pets, commonly administered in scenarios such as travel or post-injury rest. It is important to note that Acepromazine is not an anxiety medication and does not effectively treat anxiety-related conditions like separation anxiety or phobias.

Skeletal formula of Acepromazine

Missed doses and Changing medications

This medication is generally given on an as-needed basis and should not be administered more frequently than every 8 hours unless directed by your veterinary team.

Monitoring

Acepromazine is typically used for short-term care, not extending beyond a few weeks. Your pet may become accustomed to the medication over time, potentially requiring dosage adjustments. Please contact your veterinarian to discuss any changes in dosing.

Potential Side effects

The most common side effect of Acepromazine is sedation. In certain cases, particularly in less tolerant patients or when combined with other medications, this sedation can be excessive, causing symptoms such as dizziness or difficulty walking. While most patients will recover with time, veterinary advice should be sought if concerns arise.
In high doses, Acepromazine can cause low blood pressure and a slow heart rate, although this is rare with standard oral doses. If your pet becomes unresponsive, seek urgent veterinary care.
Historically, there were concerns that Acepromazine might cause seizures. However, several studies, alongside Dr. Jurney’s personal experience, have demonstrated that Acepromazine does not increase seizure risk. Dr. Jurney now considers it safe to use in patients with seizures.
Dysphoria, characterized by abnormal activity or vocalizations, can occur with sedatives, particularly when combined with pain medications. Symptoms may include frantic vocalizations such as whining or crying, and pets may appear agitated, similar to a "rowdy drunk." Dysphoric animals often benefit from being in a calm, quiet environment to allow their bodies to process the medication. If your pet exhibits signs of dysphoria, a dosage adjustment, a different medication combination, or an alternative medication may be necessary. If you have concerns or wish to discuss changes to your pet’s medication, please contact your veterinarian.
There are reports of fainting and heart arrhythmias with the use of this drug in Boxers, and it should be used with caution in this breed.