SAMe and Silybin (Denamarin®)

Intro

This is a supplement that is given to support the liver. It can be given in a preventative fashion, for instance if a dog is on another medication with known potential liver complications. It is also used when a pet has active liver disease. Because this medication is a supplement, the claims have not been verified by the FDA. However, several veterinary studies support its use both preventatively and as a treatment.

Missed doses and Changing medications

Denamarin is usually given twice a day initially. The dose frequency may be reduced over time.

Denamarin should be given on an empty stomach. This means no food or medications may be given within an hour of giving denamarin.

If your pet is on the tablet form, the tablets should not be crushed. There is also a chewable form, which some pets prefer.

Monitoring

Please contact your veterinarian to discuss any dose changes with this medication.

Side effects

This medication is generally well tolerated. Most animals will not experience any side effects with this drug. The following side effects are uncommonly reported:

1. Gastrointestinal upset including inappetence, vomiting and diarrhea

2. There is a possibility that animals who are allergic to the ragweed family will also be allergic to this medication.